Nakong ea seoa sena, lingaka li sebelisa li-antibodies tsa monoclonal tse tšetsoeng mali (li-antibodies tse hlahisoang ke laboratori) ho thusa bakuli ho loants'a tšoaetso ea COVID-19. Hona joale bafuputsi ba UC Davis ba leka ho etsa li-antibodies tsa monoclonal tse ka thusang ho loantša bohloko bo sa foleng. Sepheo ke ho hlahisa sethethefatsi se sa lemaletseng sa khoeli le khoeli se ka fokotsang li-opioid.
Morero o etelletsoe pele ke Vladimir Yarov-Yarovoi le James Trimmer, baprofesa Lefapheng la Physiology le Biology ea Membrane Univesithing ea California, Davis School of Medicine. Ba ile ba bokella sehlopha sa lihlopha tse ngata tse kenyelletsang bafuputsi ba bangata ba neng ba leka ho fetola chefo ea tarantula hore e be li-painkillers.
Pejana selemong sena, Yarov-Yarovoy le Trimmer ba ile ba fumana thuso ea $ 1.5 milione ho tsoa lenaneong la National Institutes of Health's HEAL, e leng boiteko bo matla ba ho potlakisa litharollo tsa mahlale ho ba le koluoa ea naha ea opioid.
Ka lebaka la bohloko bo sa foleng, batho ba ka lemalla li-opioids. Setsi sa Naha sa Lipalopalo tsa Bophelo bo Botle sa Litsi tsa Taolo ea Mafu se hakanya hore ho tla ba le batho ba 107,622 ba bolailoeng ke lithethefatsi United States ka 2021, hoo e batlang e le 15% ho feta mafu a hakanyetsoang a 93,655 ka 2020.
"Tlhaloso ea morao-rao ea baeloji ea meralo le ea computational - tšebeliso ea lik'homphieutha ho utloisisa le ho etsa mohlala oa mekhoa ea likokoana-hloko - e thehile motheo oa tšebeliso ea mekhoa e mecha ea ho theha li-antibodies e le batho ba babatsehang ba lithethefatsi bakeng sa ho phekola bohloko bo sa foleng," ho boletse Yarov. Yarovoy, moetsi ea ka sehloohong oa khau ea Sai.
"Li-antibodies tsa monoclonal ke sebaka se holang ka potlako indastering ea meriana 'me se fana ka melemo e mengata ho feta litlhare tse nyane tsa molek'hule," ho boletse Trimmer. Lithethefatsi tse nyenyane tsa molek'hule ke lithethefatsi tse kenang liseleng habonolo. Li sebelisoa haholo meriana.
Ho theosa le lilemo, lab ea Trimmer e thehile likete-kete tsa li-anti-monoclonal tse fapaneng bakeng sa merero e fapaneng, empa ona ke teko ea pele ea ho theha lesole la 'mele le etselitsoeng ho kokobetsa bohloko.
Le hoja e shebahala e le bokamoso, US Food and Drug Administration e amohetse li-antibodies tsa monoclonal bakeng sa phekolo le thibelo ea migraine. Lithethefatsi tse ncha li sebetsa ho protheine e amanang le migraine e bitsoang calcitonin gene-related peptide.
Morero oa UC Davis o na le sepheo se fapaneng - liteishene tse khethehileng tsa ion liseleng tsa methapo tse bitsoang li-voltage-gated sodium channels. Mecha ena e tšoana le "li-pores" liseleng tsa methapo.
“Lisele tsa methapo ke tsona tse ikarabellang bakeng sa ho fetisa matšoao a bohloko ’meleng. Mecha ea ion ea sodium e ka bang teng liseleng tsa methapo ke tsona tse fetisang bohloko, "ho hlalosa Yarov-Yarovoy. "Sepheo sa rona ke ho theha li-antibodies tse tlamahanyang libaka tsena tse khethehileng tsa phetisetso boemong ba limolek'hule, li thibela mosebetsi oa tsona le ho thibela phetiso ea matšoao a bohloko."
Bafuputsi ba ile ba lebisa tlhokomelo ho liteishene tse tharo tse khethehileng tsa sodium tse amanang le bohloko: NaV1.7, NaV1.8, le NaV1.9.
Sepheo sa bona ke ho etsa li-antibodies tse lumellanang le likanale tsena, joalo ka senotlolo se notlollang senotlolo. Mokhoa ona o lebisitsoeng o etselitsoe ho thibela phetiso ea matšoao a bohloko ka mocha ntle le ho kena-kenana le matšoao a mang a fetisitsoeng ka lisele tsa methapo.
Bothata ke hore sebopeho sa likanale tse tharo tseo ba lekang ho li thibela li rarahane haholo.
Ho rarolla bothata bona, ba retelehela ho mananeo a Rosetta le AlphaFold. Ka Rosetta, bafuputsi ba ntse ba hlahisa mefuta e rarahaneng ea liprotheine tsa sebele 'me ba hlahloba hore na ke mefuta efe e loketseng hantle likanale tsa NaV1.7, NaV1.8, le NaV1.9 neural. Ka AlphaFold, bafuputsi ba ka lekola liprotheine tse entsoeng ke Rosetta ka boikemelo.
Ha ba se ba tseba liprotheine tse 'maloa tse ts'episang, ba thehile li-antibodies tse neng li ka lekoa lithaneng tsa neural tse entsoeng ka laboratoring. Liteko tsa batho li tla nka lilemo.
Empa bafuputsi ba thabetse bokhoni ba mokhoa ona o mocha. Non-steroidal anti-inflammatory drugs (NSAIDs), tse kang ibuprofen le acetaminophen, li tlameha ho nooa hangata ka letsatsi ho kokobetsa bohloko. Hangata li-painkillers tsa opioid li nkoa letsatsi le leng le le leng 'me li na le kotsi ea ho lemalla.
Leha ho le joalo, li-anti-monoclonal antibodies li ka potoloha maling nako e fetang khoeli pele li qetella li robehile ke ’mele. Bafuputsi ba ne ba lebelletse hore bakuli ba iketsetse li-analgesic monoclonal antibody hang ka khoeli.
"Bakeng sa bakuli ba nang le bohloko bo sa foleng, sena ke sona seo u se hlokang," ho boletse Yarov-Yarovoy. Ha ba utloe bohloko ka matsatsi a mangata, empa ka libeke le likhoeli. Ho lebelletsoe hore li-antibodies tse potolohang li tla khona ho fana ka phomolo ea bohloko e nkang libeke tse 'maloa. ”
Litho tse ling tsa sehlopha li kenyelletsa Bruno Correia oa EPFL, Steven Waxman oa Yale, William Schmidt oa EicOsis le Heike Wolf, Bruce Hammock, Teanne Griffith, Karen Wagner, John T. Sack, David J. Copenhaver, Scott Fishman, Daniel J. Tancredi, Hai Nguyen, Phuong Tran Nguyen, Diego Lopez Mateos, le Robert Stewart oa UC Davis.
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Nako ea poso: Sep-29-2022